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Cholesterol: Friend and Foe
Cholesterol is a familiar term in contemporary discussions concerning health and heart disease. Primarily synthesized by our
own bodies, 1 the ability to function diversely in cell membranes and various organ systems is one characteristic of this
molecule. However, its presence is not 2 profitable in all circumstances: when an individual consumes food that leads to high
blood cholesterol levels, significant health complications may result. Because this molecule plays such a critical role in our
health, it's important to understand its function and recognize the dangers associated with having high cholesterol levels.
Cholesterol molecules have a diverse range of functions within the human body, whether in cell membranes or as 3 part of: the
nervous, endocrine, or digestive systems. In part due to its rigid, tetracyclic structure, cholesterol contributes to the structural
integrity of cell membranes. A research study conducted by Sheng et al. revealed that membrane cholesterol also participates in
cellular signaling through binding to specific domains of some proteins. Furthermore, cholesterol is a key component of the
central nervous system, where it primarily 4 existed in the myelin sheaths of nerve cells; these sheaths help increase the speed
of nerve impulse transmission. 5 In addition to these functions, cholesterol is an important precursor to bile acids of the
digestive system and steroids of the endocrine system.
6 To illustrate the importance of contemporary research on cholesterol, its presence in abnormally high concentrations can
result in significant health issues. Many researchers believe that certain dietary 7 choices, for example, eating—significant
amounts of saturated fats and avoiding unsaturated fats—contribute to high cholesterol levels in the bloodstream. Since
cholesterol molecules do not dissolve in water or blood, 8 they are also transported to various parts of the body by lipoproteins,
which are constructed from both fats and proteins.9 When the concentration of LDL cholesterol is high, it may clog an
individual’s arteries and lead to a variety of medical conditions.
Notwithstanding the health risks associated with high cholesterol levels, it is important to remember that this molecule
is 10 integral to many necessary and vital life functions. From the structure of cell membranes to the swift conduction of nerve
impulses, from digestion to hormone production, many physiological structures and processes depend on cholesterol.
Consequently, 11 it’s important to fund future research initiatives that investigate the significance of this molecule.
1
A. NO CHANGE
B. cell membranes and various organ systems offer locations for this molecule to function.
C. the diverse functions of this molecule extend to cell membranes and various organ systems.
D. this molecule has diverse functions in cell membranes and various organ systems.
2
A. NO CHANGE
B. beneficial
C. charitable
D. worthy
3
A. NO CHANGE
B. part; of the nervous, endocrine,
C. part of the nervous, endocrine,
D. part of the nervous; endocrine;
4
A. NO CHANGE
B. was existing
C. had existed
D. exists 5 At this point, the writer is considering adding the following sentence.
Successful nerve impulse transmission depends not only on myelin sheaths, but also on the presence of ion pumps embedded in
the cell membrane.
Should the writer make this addition here?
A. Yes, because it describes how the presence of ion pumps is related to the functions of cholesterol.
B. Yes, because it supports the passage’s main argument with a second example of cholesterol’s potential adverse health
effects.
C. No, because it identifies a relationship between the nervous system and ion pumps that has already been discussed.
D. No, because it interrupts the paragraph’s discussion of cholesterol’s functions with loosely related information.
6 Which choice provides the best transition?
A. NO CHANGE
B. Despite the numerous positive functions of cholesterol,
C. Considering the many sources of cholesterol,
D. Even though cholesterol can bind to some proteins,
7
A. NO CHANGE
B. choices; for example, eating substantial amounts of saturated fats and avoiding unsaturated fats;
C. choices—for example, eating substantial amounts of saturated fats and avoiding unsaturated fats—
D. choices, for example: eating substantial amounts of saturated fats and avoiding unsaturated fats,
8
A. NO CHANGE
B. that is
C. it is
D. this is
9 At this point, the writer wants to add details about the specific functions of lipoproteins. Which choice most effectively
accomplishes this goal?
A. There are many different types of lipoproteins, including very low density lipoproteins, intermediate density lipoproteins,
low density lipoproteins, and high density lipoproteins.
B. While the liver is the primary organ of lipoprotein synthesis, research has demonstrated that chylomicrons, a type of
lipoprotein, are synthesized in the mucosa of the small intestine.
C. Low density lipoproteins (LDL) carry cholesterol into the bloodstream and various parts of the body, while high density
lipoproteins (HDL) remove cholesterol from the bloodstream for disposal.
D. Lipoproteins are classified by density, which can be calculated from the ratio of triacylglycerol/protein concentration and
the actual diameter of the molecule.
10
A. NO CHANGE
B. integral to many necessary
C. integral and vital to many necessary
D. necessary and vital to many integral
11 Which choice best concludes the passage?
A. NO CHANGE
B. everyone should focus on more important dietary issues than cholesterol consumption.
C. it’s important to understand why cholesterol is insoluble in both water and blood.
D. maintaining a healthy cholesterol level is a step toward a healthy life.
DBCDD BCACB D
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